Friday 2 August 2013

What are the biomarkers of aging?

Current research is looking closely into the process of aging and seeking ways to slow it down. In order to test new drugs, there has to be a way to determine if the intervention is having an impact on the underlying process of aging— not just whether it has an effect on one of the body’s systems, such as affecting blood pressure or cholesterol levels, but whether it slows down the actual aging process.

Currently, the only way to test drugs that are aimed at extending life is to conduct studies that follow subjects to the end of their lives. This can take an impractically long time. What’s needed are biomarkers of the aging process that could help determine a person’s life expectancy, making it unnecessary to wait many years for the results of studies. If a set of biomarkers of aging were identified, it would also have the effect of demonstrating that there actually is an underlying mechanism of aging that coordinates changes across the body’s systems.

I make my point clear with the example. There was a research aimed at Identification of Biomarkers of Human Skin Ageing in Both Genders.  The goal of our work has been to investigate the mechanisms of gender-independent human skin ageing and examine the hypothesis of skin being an adequate model of global ageing. Research showed that only 4 overlapping gene OR52N2F6FR1OP2TUBAL3 and STK40 showed differential regulation with age. Interestingly, Wnt signaling pathway showed to be significantly downregulated in aged skin with decreased gene and protein expression for males and females. In addition, several genes involved in central nervous system (CNS) ageing showed to be expressed in human skin and were significantly regulated with age. Thus, the WNT-signaling pathway could be a good biomarker of aging.

Read more: PLOSONE

Watch more: YOUTUBE

Picture: Aging Kills You

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