Saturday, 26 October 2013

Big step up!

I love very much my (ex)Intitute, Moscow Institute of Physics and Technology. However, there are some points in MIPT's policy, which should be improved.

I think, that one of the most importatant such points is an internalization. In MIPT courses are offered only in Russian, and that prevents international student apply to the Institute. But a big step up was made recently! Courses of MIPT appeared at Coursera! Now MIPT is one step closer to top 100 best universities of the world.

Thursday, 3 October 2013

Why We Should Look Forward To Living To 120 And Beyond?

I am doing ageing research and happy about it, but a lot of my friends ask me:"Why are you doing this?". I have a lot of personal reasons, for example, because I am in love with my life or I do not want to look like wrinkled pea and to be disabled. However, sometimes it is now enough to persuade people to do ageing research or give money to support science.

Now, thanks to article by  Dr.Alex Zhavoronkov in Forbes I know even more reasons, why governments of all countries should pay greater attention to ageing research.  

According to the article, 

" There are clear benefits, then, in proactively stretching your expected life horizon to a number much greater than your can currently imagine. It will probably not only make you look and feel younger, but also induce the behavioral patterns of someone more youthful, enabling you to interact with younger and older people without barriers and remain productive longer than your peers.

Another benefit of setting the bar toward 120, 150 or beyond is minimizing financial risk. This will most certainly lead more of us to postpone retirement and set a course for continuous improvement, lifelong learning and active career planning.

There is definitely no harm in stretching your “ageometer” to 150. Most likely technology will catch up and exceed your expectations. The worst that can happen is you will die earlier feeling much younger than you ever thought you would. "

I high recommend you to read this article!

Image by thinkstock

Tuesday, 1 October 2013

A group of my colleagues proposed novel ways to prevent and combat the age-related mineralization of the connective tissue

My friends and colleagues, Anastasia Shyndyapina, Garik V Mkrtchyan, Tatiana Gneteeva (, Sveatoslav Buiucli, Alexander Aliper, Alexander Zhavoronkov together with the Canadian scientists M Kulka, B Tancowny just got their paper accepted in Rejuvenation Research, a leading journal in biogerontology.

Mineralization is a very important problem in aging and I would like you to take a look at their press release below. By the way, I am also part of the FOIRMYS initiative and spent a year in two of their group projects focusing on other aspects of aging research.

The press release: 

When you open a 70-year old patient on the operating table and touch the aorta, the feeling may resemble touching an eggshell or sand paper. It is stiffer than the heart of a young person and the key reasons for this are the abundant calcium deposits in the connective tissue that accumulate with age.

The many factors leading to mineralization of the connective tissue include genetic and acquired diseases, inflammation, reactive oxygen species, but the major problem is that it occurs spontaneously during aging as calcium-containing molecules are trapped in the extracellular matrix and develop into apatite over time.

Despite its relative significance, compared to the many other areas of aging research, mineralization of the connective tissue is rarely mentioned in scientific publications and few teams are working on preventing or clearing out the extracellular aggregates.  To address the problem, a multidisciplinary team of physicians, bioinformatitians, biochemists and physicists performed a comprehensive bioinformatics analysis of the many factors involved in mineralization, identified key molecular targets and proposed a list of possible drugs to address the issue.

The results of the study were accepted for publication by a high-impact journal in biogerontology “Rejuvenation Research” and will be published shortly and can be cited as “Mineralization of the connective tissue: a complex molecular process leading to age-related loss of function”, Anastasia Shindyapina, Garik V Mkrtchyan, Tatiana Gneteeva, Sveatoslav Buiucli, M Kulka, B Tancowny, Alexander Aliper, Alexander Zhavoronkov, Rejuvenation Research, ahead of print. doi:10.1089/rej.2013.1475, , PMID 23902273

Anastasia Shindyapina together with her collaborators presented the results of the study on the 5th of September at the SENS6 conference in Cambridge, UK.

“Aging inevitably leads to the loss of function on many levels. Mineralization of the connective tissue is one of the causes and consequences of aging and is a complex multifactorial process. Metabolic activity, diseases and external stress factors may cause calcification, but most importantly, it occurs spontaneously. Our goal is to identify least toxic ways to both prevent calcification and to repair the accumulated  aggregates.”, said Anastasia Shindyapina, ASUS Fellow for Bioinformatics and Medical Information Technology, PhD-candidate at the Moscow State University and researcher at FOIRMYS.

"Mineralization of connective tissue with age is one of the many aspects of aging that are examples of "accumulation of eventually pathogenic extracellular material", an issue that attracts too little attention within the academic community. The accumulation of advanced glycation endproducts (AGEs) and of mineral deposits both result in increased stiffness of connective tissue, impair homeostasis and contribute to a broad range of age-related diseases. Through comprehensive bioinformatic analysis of the many molecular processes involved in mineralization, Zhavoronkov's team has identified possible molecular interventions. Additionally they proposed that mineralization and AGEs work in concert and should be addressed concurrently. Anastasia Shyndyapina, the lead author on the paper, recently presented this work at the SENS6 conference in Cambridge.", commented Dr. Aubrey de Grey, Chief Science Officer of SENS Research Foundation and International Adjunct Professor at the Moscow Institute of Physics and Technology (MIPT).

The First Open Institute for Regenerative Medicine for Young Scientists (FOIRMYS) is a non-profit volunteer initiative bringing together over a thousand enthusiast young scientists and physicians interested in regenerative medicine. It was first organized by Alex Zhavoronkov, PhD in collaboration with Sergey Yakovenko, PhD, Sergey Roumiantsev, PhD and Oleg Korzinov in Moscow with support from Anna Chapman.
FOIRMYS provides regular weekly lectures by the top academic and industry thought leaders, investors and regulators. The list of presenters includes Paolo Macchiarini (Karolinska Institute), Alexey Aravin (Caltech), Charles Cantor (Boston U, ex-director of the Human Genome Project), Augustinus Bader (Leipzig University), top managers from Beijing Genomics Institute, Malaysian Genome Resource Center, Indigo Capital Partners and many others. As part of the curriculum students participate in practicums at “Altravita IVF, FRCCPH, FORCC, Quantum Pharmaceuticals, Biopharmcluster “Northern” and Moscow Institute of Physics and Technology.
Members work in small teams comprised of scientists and physicians on ambitious outlier projects in aging and regenerative medicine with topics ranging from mineralization of connective tissue, HGPS and regulation of endometriosis to industry overviews and healthcare economics. The projects are coordinated in a crowdsourced environment and rely heavily on popular tools like Facebook, Dropbox and Google Apps. FOIRMYS developed a concept called “Personalized Medicine”, where projects are centered around the problems of a single patient, who provides samples and helps coordinate the project. Members also learn how to promote their work, create personal science blogs (including Women in Science initiative) and engage in industry outreach.
Participation in practical group projects resulted in success stories including young scientists’ publications in peer-reviewed journals, fellowships, participation in international conferences, gainful employment of young scientists and international collaborations.