The wrinkles

When I think about aging, the first thing that is coming to my mind is wrinkles. You can easily figure out person’s age just take a look on his or her face. In my opinion, wrinkles are a kind of skin decease, associated with aging, and we definitely should fight them and do not only mask them. I do not believe in some “wonderful” creams, but I believe in science and in this post I will give a general overview of new strategies to reduce wrinkles based on molecular approach.

 

 Skin aging is a complex process combined with intrinsic and extrinsic factors. Intrinsic or chronological skin aging results from the passage of time and is influenced by genetic factors. Extrinsic skin aging is mainly determined by UV irradiation, also called photoaging. These two types of aging processes are superimposed on sun-exposed skin, and have a common feature of causing dermal matrix alterations that mostly contribute to the formation of wrinkles, laxity, and fragility of aged skin. The dermal matrix contains extracellular matrix proteins such as collagen, elastin, and proteoglycans that confer the strength and resiliency of skin. Thus, it is necessary to stop the degradation of the skin primary structural constituents, such as collagen, elastin, to prevent the formation of wrinkles. Recent research showed that a drug with naturally occurring matrix of hydrolyzed collagen type II and low-molecular-weight hyaluronic acid and chondroitin sulfate have a great positive effect on skin health. Daily supplementation with 1 g of such substance for 12 weeks led to a significant reduction of skin dryness/scaling (76%) and global lines/wrinkles (13.2%). .You can read more about the drug here.

 

Another way to handle with aging of skin matrix is to use inhibitor of cyclooxygenase-2 (COX-2).  It has been proposed that the pro-inflammatory catalytic activity of COX-2 plays a key role in the aging process. A COX-2 inhibitor, NS-398 was shown to reduce skin aging by regulating the expression of type I procollagen and caveolin-1 and reducing the expression of p53 and p16 (oncogenes). So the injection of NS-398 can be the way to cure wrinkles.

 

However, I have my own idea. A small balls made from thin rubber should be placed around the wrinkle. After that the water or some liquid should be placed in this balls, the balls will become bigger and cause the growth of healthy skin. When new skin could replace the skin with wrinkle, the old skin should be replaced. Thus we have healthy new skin.

If you read more about skin anti-aging strategies: NCBI

Sourse:NCBI